Molecular Frontiers of Cancer

Cancer, a complex group of diseases characterized by uncontrolled cell growth, poses a formidable challenge worldwide. Its impact on society is profound, affecting millions of lives and presenting a substantial burden on healthcare systems. The need for comprehensive research to unravel the intricacies of cancer biology and develop advanced strategies for diagnosis and treatment has never been more crucial.

The Cancer Research Program at CIC bioGUNE is a multidimensional exploration focused on unraveling the complexities of cancer, specifically targeting Prostate, Breast, Colorectal, and Liver cancers. 

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This program encompasses several crucial research areas:

• Molecular Basis of Cancer Progression: Investigating the molecular signatures and signaling pathways that drive the progression of Prostate, Breast, Colorectal, and Liver cancers. Our goal is to identify potential targets for precision medicine and advance the development of tailored therapeutic interventions.

• Precision Medicine in Cancer Treatment: Applying precision medicine approaches to develop targeted therapies for different cancer types. This includes deciphering the genetic and molecular variations that contribute to cancer heterogeneity and tailoring treatments accordingly.

• Biomarker Discovery for Diagnostic Advancements: Identifying and validating biomarkers that enhance cancer diagnostics and prognostics. Through advanced molecular profiling and bioinformatics analyses, we aim to contribute to the development of reliable biomarkers for various cancer types.

Molecular Perspectives of Rare Diseases

Rare diseases, often referred to as orphan diseases, encompass a broad spectrum of disorders that collectively affect a relatively small number of individuals within a population. These diseases are characterized by their low prevalence, typically afflicting fewer than 1 in 2,000 people. Despite their individual rarity, the cumulative impact of rare diseases is substantial, with estimates suggesting that there are thousands of distinct rare diseases, collectively affecting millions of people worldwide.

Many rare diseases are chronic, debilitating, and life-threatening, often manifesting early in life. Due to their complex and often unpredictable nature, these diseases can lead to significant physical, emotional, and financial burdens on patients and their caregivers. Moreover, the lack of effective treatments exacerbates the challenges faced by individuals living with rare diseases.

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The importance of research dedicated to rare diseases lies in its potential to unravel the underlying molecular mechanisms, genetic factors, and cellular processes driving these conditions. Investigating genetic mutations associated with rare diseases provides crucial insights into the fundamental aspects of human biology and the consequences of genetic abnormalities. Understanding the molecular basis of disease progression is essential for developing targeted therapies that can alter the course of the disease, improving the quality of life for affected individuals.

The impact of rare diseases research extends beyond the laboratory, directly influencing clinical practice, healthcare policies, and societal perceptions. By identifying potential therapeutic targets, researchers contribute to the development of novel treatment approaches and pave the way for precision medicine tailored to the unique genetic and molecular profiles of individuals with rare diseases. Additionally, advancements in rare diseases research contribute to the broader understanding of biological processes, benefiting the entire field of medicine.

The Rare Diseases Research Program at CIC bioGUNE plays a pivotal role in addressing the challenges posed by rare diseases. By exploring the intricate molecular pathways, genetic factors, and cellular mechanisms associated with rare diseases, the program contributes not only to scientific knowledge but also to the development of innovative diagnostic methods and targeted therapeutic strategies. The societal impact of this research is substantial, offering hope and improved outcomes for individuals grappling with rare diseases and their families.

CEITEC Masaryk University

Harnessing knowledge of plant biology for crop improvement, infectious diseases; RNA/nucleic acids in health and disease; correlative approaches to connect dynamics and structure of living systems; cancer biology; and brain disorders.